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Zheng Yi is a 3D Character Designer and 3D Character Animator. can create a 3D character with a blank 3D character, and, no need to model or 3D animating some other time. copy your own 3D character, make any edits to the…Inhibition of differentiation of leukaemic cells via induction of erythroid lineage.
Differentiation of leukaemic myeloid or monocytic progenitor cells is inhibited by treatment of the cells with various human and murine recombinant factors, including monocyte-macrophage colony-stimulating factor (M-CSF). We report the effects of M-CSF and its receptor (c-fms) on differentiation of murine erythroleukaemia (MEL) cells. M-CSF acts on the monocytes to promote proliferation and to inhibit their differentiation. The molecular mechanism involves autocrine secretion of a soluble growth factor of the p55 class of the receptor for c-fms. c-fms is a three-chain protein composed of the ligand-binding alpha-chain and two homologous transmembrane beta-chains. The transient expression of a carboxyl-terminal truncated form of c-fms in MEL cells shows that part of the p55 alpha-chain of c-fms is involved in the inhibitory function. This truncated form is able to inhibit differentiation of the cells. The mechanism involves, as shown with other effectors, inhibition of the stimulatory effect of the inducing agent, hemin.[Ultrasonic evaluation of liver function in patients with exogenous obesity].
Comprehensive ultrasound investigations were performed in 50 normal persons and in 193 obese patients (BMI > 30). Ultrasound signs of the fatty liver and its’ complications were found in 34.6% of the normal persons and in 24.9% of the obese (significantly more frequent in the women than in the men). Low and high ultrasound echoes corresponded to the greater prevalence of fatty degeneration of the liver and steatosis. Fatty degeneration of the liver is associated with the content of excessive lipids in the blood, and with the higher levels of triglycerides. Fatty degeneration of the liver aggravates during obesity. The findings confirm that early changes of the liver in obese individuals should be taken into account when making decisions about the performance of dynamic

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